Chronic thromboembolic pulmonary hypertension and left ventricular filling pressures

Abstract Background Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by chronic obstruction of major arteries with organized thrombi and classified as pre-capillary (PH) the current hemodynamic definition guidelines. However, clinical risk factors for PH due to left heart disease including features metabolic syndrome, left-sided valvular stable ischemic can be frequently observed in patients CTEPH. The aim this study was investigate prevalence, mechanisms prognostic implications elevated ventricular filling pressures (LVFP) Methods 394 consecutive CTEPH undergoing a first diagnostic right catheterization were included study. mPAWP LVEDP utilized assessment LVFP. Two cutoffs applied identify LVFP: (1) and/or >15 mmHg recommended guidelines (2) >11 mmHg, which upper limit normal healthy subjects. Clinical echocardiographic well long-term mortality data assessed. Results LVFP 41 (10.4%) 155 (39.3%). Univariable logistic regression analysis identified age, body mass index, systemic hypertension, diabetes, atrial fibrillation, mitral regurgitation volume significant predictors Systemic remained independent determinants adjusted analysis. associated worse survival (p-logrank = 0.020). Conclusions Elevated common at time diagnosis. appears comorbid disease. have outcomes. Funding Acknowledgement Type funding sources: None.